Precision targeting of specific white matter bundles that traverse the subcallosal cingulate has been linked to efficacy of deep brain stimulation for treatment resistant depression. Methods to confirm optimal target engagement in this heterogenous region are now critical to establish an objective treatment protocol. As yet unexamined are the time-frequency features of the SCC evoked potential, including spectral power and phase-clustering. We examined these spectral features—evoked power and phase clustering—in a sample of TRD patients with implanted SCC stimulators. Electroencephalogram was (...) recorded during wakeful rest. Location of electrical stimulation in the SCC target region was the experimental manipulation. EEG was analyzed at the surface level with an average reference for a cluster of frontal sensors and at a time window identified by prior study. Morlet wavelets generated indices of evoked power and inter-trial phase clustering. Enhanced phase clustering at theta frequency was observed in every subject and was significantly correlated with SCC-EP magnitude, but only during left SCC stimulation. Stimulation to dorsal SCC evinced stronger phase clustering than ventral SCC. There was a weak correlation between phase clustering and white matter density. An increase in evoked delta power was also coincident with SCC-EP, but was less consistent across participants. DBS evoked time-frequency features index mm-scale changes to the location of stimulation in the SCC target region and correlate with structural characteristics implicated in treatment optimization. Results also imply a shared generative mechanism between evoked potentials evinced by electrical stimulation and evoked potentials evinced by auditory/visual stimuli and behavioral tasks. Understanding how current injection impacts downstream cortical activity is essential to building new technologies that adapt treatment parameters to individual differences in neurophysiology. (shrink)

Physicalism is standardly construed as a form of monism, on which all concrete phenomena fall under one fundamental type. It is natural to think that monism, and therefore physicalism, is committed to a supervenience claim. Monism is true only if all phenomena supervene on a certain fundamental type of phenomena. Physicalism, as a form of monism, specifies that these fundamental phenomena are physical. But some argue that physicalism might be true even if the world is disorderly, i.e., not ordered by (...) supervenience relations in the way commonly supposed (Montero in J Philos 110:92–110, 2013; Leuenberger in Inquiry 57:151–174, 2014; Montero and Brown in Topoi 37(3):523–532, 2018; Zhong in Philos Stud 178(5):1529–1544, 2021). Unless these authors intend to challenge the claim that physicalism is a type of monism—a claim so central to the dialectic in philosophy of mind that rejecting it risks changing the subject—they are committed to challenging a supervenience requirement for monism. We argue that monism entails that there are substantial supervenience relations among concrete phenomena: relations that would not obtain in a disorderly world. Our argument thus has implications for debates about physicalism and supervenience, and sheds light on an under-discussed issue: what is implied by classifying a theory in the philosophy of mind as a form of monism? We also argue that physicalism’s commitment to monism creates problems for _via negativa_ physicalism, on which the physical is characterized negatively. (shrink)

This paper explores The New Rhetoric’s concept of universal audience in the contexts of philosophical and traditional rhetorical discourse. It argues that, since Perelman’s final English-language article, published in 1984 to clarify misunderstandings among rhetorical scholars about his theory, rhetorical scholars have persisted in three primary misconceptions of the concept of universal audience: appeals to the real are made only to universal audiences, only universal audiences are qualified to establish the reasonableness of arguments, and only universal audiences prevent The New (...) Rhetoric’s rhetorical theory from degenerating into relativism. It explains why each of these misconceptions is inaccurate and provides a corrected view of universal audience that places it exclusively in the province of philosophical discourse. Finally, it questions whether constructed audiences in general add explanatory power to rhetorical analyses or are merely unnecessary constructs that should be dispensed with for the sake of theoretical parsimony. (shrink)

Medical education at the Colombian School of Medicine has undergone a reconceptualization and reorganization so as to encompasses three fundamental elements of medical practice: 1) development of general abilities and standards necessary for appropriate professional medical practice; 2) technical education which makes it possible to utilize the bases that science and technology have provided for the development and application of knowledge, and in turn, to expand this base through research and development; and 3) humanistic education to guide students into ethical (...) professional practice. (shrink)

The recent far-reaching developments of Physics have produced the widespread impression that all those ideas of mechanics and mechanism, which were so influential in the nineteenth century, have now been completely abandoned, because they have proved to be quite inadequate as explanations, or even as mere descriptions, of the ultimate constitution of the physical world. “Has not modern physics”, asks Prof. Millikan, “thrown the purely mechanistic view of the universe root and branch out of its house?“ It is frequently contended, (...) still further, that the place of these concepts has been taken by others, very closely approximating to biological, or even to psychological, interpretations of all natural phenomena; the physics of today, in short, and yet more of tomorrow, is essentially non-mechanical. (shrink)